• Division of Alcoholic Beverage and Tobacco issues licenses and permits that are required for any person or business to manufacture, import, export, store, distribute, or sell alcoholic beverages or tobacco.
• Division of Certified Public Accounting regulates Certified Public Accountants and accounting firms.
• Division of Drug, Devices and Cosmetics safeguards the citizens of the state of Florida from injury due to the use of adulterated, contaminated, or misbranded drugs, drug ingredients, and cosmetics by administering the provisions of the Florida Drug and Cosmetic Act.
• Division of Condominiums, Time Shares, and Mobile Homes helps protect Floridians by regulating condominiums, cooperatives, timeshares, and mobile home parks. The division also licenses and regulates yacht and shipbrokers.
• Division of Hotels and Restaurants protects the health and safety of the public by inspecting and regulating public lodging and food service establishments. The division also licenses and regulates elevators, escalators, and other vertical conveyance devices.
• Division of Pari-Mutuel Wagering ensures compliance with state laws for such activities as horse racing, jai alai games, card-room poker games, and slot machines while also collecting and safeguarding revenues due the state from these activities.
• Division of Professions licenses over 460,000 diverse professionals, such as architects, auctioneers, barbers, electrical contractors, interior designers, and veterinarians.
• Division of Real Estate conducts examinations, licensing, and regulatory activities to the more than 400,000 real estate professionals, corporations, schools, and instructors operating in the state.
• Division of Regulation monitors professionals and related businesses licensed by the department to help ensure compliance with all applicable laws, rules, and licensing standards.
• Division of Service Operations manages the Central Intake and Licensure unit, which is the one-stop shop for the intake of applications and payments. The division also oversees the Customer Contact Center, which handles all initial interaction conducted via telephone, e-mail, and the internet.
• Florida Building Commission develops, maintains, and interprets the Florida Building Code through a consensus-building process within the 25-member technical body.
• Florida Athletic Commission regulates professional boxing, kickboxing, and mixed martial arts and approves amateur sanctioning organizations that supervise these activities at the amateur level.

New Gaming Compact Signed. During the 2021 special session, the Florida Legislature enacted CS/SB 2-A , which ratified the 2021 Gaming Compact between the State of Florida and the Seminole Tribe of Florida. The state is guaranteed $2.5 billion over the first five years and additional funds during later years from a revenue sharing formula. The compact permits the tribe to offer table games, such as craps and roulette, as well as its previous games. The compact permits betting on professional and college sports as long as the bets are placed in Florida and processed through a sports book operated by the tribe. Under the compact, pari-mutuel permit holders can offer sports betting if it is conducted through the tribe's sports book and can continue to operate card rooms if licensed as of January 1, 2021. The compact also permits the tribe to add three new facilities within its Hollywood Reservation. The compact ends July 31, 2051.

• Division of Alcoholic Beverage and Tobacco, Chs. 210, 386, 561, 562, 563, 564, 565, 567, 568, and 569, and ss. 322.212, 559.791, 768.125, and 877.18, Florida Statutes.
• Division of Certified Public Accounting, Chs. 455 and 473, Florida Statutes.
• Division of Drugs, Devices and Cosmetics, Ch. 499, Florida Statutes.
• Division of Condominiums, Time Shares, and Mobile Homes, Chs. 326, 718, 719, 720, 721, and 723, Florida Statutes.
• Division of Hotels and Restaurants, Chs. 83, 386, 399, 509, and 559, and s. 865.09, Florida Statutes.
• Division of Pari-Mutuel Wagering, Chs. 550, 551, and 849, and s. 285.710, Florida Statutes.
• Divisions of Professions and Regulation, Chs. 310, 447, 450, 455, 468, 469, 474, 476, 477, 481, 489, 492, and 548, Florida Statutes.
• Division of Real Estate, Chs. 455 and 475, Florida Statutes.
• Division of Service Operations, Chs. 20, 23, 116, 120, and 455, Florida Statutes.
• Florida Building Commission, ss. 553.76 and 553.77, Florida Statutes.
• Florida Athletic Commission, Ch. 548, Florida Statutes.